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Reduced appetite that crosses the line from helpful into uncomfortable

Memantine is an uncompetitive NMDA receptor antagonist and prevents damage to AD patients caused by NMDA receptor overactivation

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Clinicians began exploring this approach for a few reasons: Not everyone needs aggressive appetite suppression to improve metabolic health Some people are more sensitive to GLP-1 medications Side effects often increase with higher doses Cost and long-term sustainability matter Women, in particular, started asking different questions